【单选题】
（2）Formulation is about the design, development and evaluation of dosage forms,___
A. discovery of novel drugs
B. analytical methods
C. drug delivery systems and manufacturing process
D. dosing regimen
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答案
C
解析
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相关试题
【单选题】
(3)Biopharmaceutics mainly studies the in vivo process of drugs and metabolites in humans, animals and tissue culture, which specifically involves___
A. absorption and distribution
B. absorption, distribution, metabolism, and excretion
C. metabolism and excretion
D. absorption and excretion
【单选题】
(4)Regarding the definition of bioavailability(BA), BA is related to___
A. total plasma drug concentration only
B. unbound drug concentration in the plasma
C. unbound drug concentration at the target site
D. total plasma drug concentration, and the administered drug dose
【单选题】
(5)Plasma drug concentration is affected by following factors such as___
A. rate of absorption
B. rate and extent of distribution
C. rate ofeli Imination
D. all ofabove
【单选题】
6)Which of the following routes of administration will involve the absorption of drugs?___
A. i.v.injection
B. i.v.infusion
C. Subcutaneous injection, transdermal and oral
D. None of above
【单选题】
（7）Which of the following factors may influence the time course of a drug in the plasma and hence at its site of action?___
A. Food
B. Disease state
C. Route of administration
D. All of above
【单选题】
(8)Please identify the potential biological barriers for an orally administered tablet to be absorbed into the systemic circulation___
A. Sk d dermis
B. Gastrointestinal epithelium
C. Oral mucosal membrane
D. All of above
【单选题】
(9) Given the same administration dose, which of the following will likely result in varying bioavailabilities for the same drug administered to the same person? ___
A. tablets (p.o. )vs. solutions(p0.)
B. solutions for injection(i v )vs oral solutions(p0.)
C. coated tablets (p.0. )vs hard gelatin capsules(p0.)
D. All ofabove
【单选题】
(10)Which of the following statements is true?___
A. Bioavailability is only related to the administered dose and the total drug concentration in the blood circulation.
B. Plasma protein binding does not affect the bioavailability of a specific drug.
C. A given drug in different dosage forms may show differences in bioavailability if given by the same route.
D. Biopharmaceutical studies do not involve animal experiment.
【判断题】
Much of our present physiological knowledge has been found from the experiments and studies on human beings.
A. 对
B. 错
【判断题】
Living cells break down glucose and fats to provide energy for other activities, which is called.
A. 对
B. 错
【判断题】
The right atriapumps deoxygenated blood to the lungs where it absorbs oxygen from the air.
A. 对
B. 错
【判断题】
The nervous system uses electrical signals to transmit information very rapidly to specific cells.
A. 对
B. 错
【判断题】
With the level of sodium increasing extracelular fruid. the cardiac muscle cells become too excitable and may contract.
A. 对
B. 错
【判断题】
A negative feedback loop is a control system that acts to maintain the level of some variables within a given range following a disturbance
A. 对
B. 错
【判断题】
(1)Pharmacodynamics, which is concerned with the study of the biochemical and physiological effects of drugs and their mechanisms of action, Is an experimental medical science.
A. 对
B. 错
【判断题】
2)It's unreasonable for a physician to be interested mainly in the effects of drugs on human beings, for the pharmacological evaluation of drugs in them may be limited due to technical, legal, and ethical reasons.
A. 对
B. 错
【判断题】
（3） As the effects of drugs are often characterized by significant interspecies variation and may be further modified by disease, clinical pharmacology has never been efibrasized.
A. 对
B. 错
【判断题】
The physician is not interested in drugs that are useful in the prevention,diagnosis,and treatment of human disease, but in chemical agents that are commonly responsible for household and industrial poisoning as well as environmental pollution.
A. 对
B. 错
【判断题】
(5)A drug is said to be useful in therapy if it has the ability to produce its desired effects with only tolerable undesired effects.
A. 对
B. 错
【判断题】
(6)Toxicology deals not only with drugs used in therapy but also with many other chemicals that may be responsible for household, environmental, or industrial intoxication.
A. 对
B. 错
【判断题】
1)With the more efficient screening tests and burgeoning knowledge about how a molecules biological activities are likely to be changed, the traditional approach of discovering new drugs has been improved.
A. 对
B. 错
【判断题】
2)With the parallel synthesis used to identify which small segment of any given large protein would bind to an antibody, Mario Geysen generated a variety of short protein fragments by combining multiple amino acids in different permutations.
A. 对
B. 错
【判断题】
)A parallel synthesis and a split-and-mix synthesis are different in that in a split-and-mix synthesis, all the products are assembled separately n their respective reaction vessels.
A. 对
B. 错
【判断题】
4) In many laboratories, robots are used in the routine work of parallel synthesis to deliver small amounts of reactive molecules into appropriate wells, thus making the process more accurate and less tedious.
A. 对
B. 错
【判断题】
5) In a parallel synthesis, each compound remains in its own container; while in a split-and-min synthesis, the related ce mpounds are mixed up in the same reaction vessel.
A. 对
B. 错
【判断题】
6)In order to solve the difficulties of identifying the compounds made in a parallel synthesis scientists pull out from the mixture the beads that bear biologically active molecules and determine the molecular makeup o d attached.
A. 对
B. 错
【判断题】
1)The concentration of a drug in whole plasma is the most accurate index of the drug concentration at the site（s） of action.
A. 对
B. 错
【判断题】
(2)It is difficult to measure the total concentration of both unbound and bound drug in total plasma.
A. 对
B. 错
【判断题】
(3)The clinical effect of a drug is assumed to be directly related to the plasma drug concentration.
A. 对
B. 错
【判断题】
(4) Systemically acting drugs administered by all routes involve the absorption of drug from the place of administration into the blood.
A. 对
B. 错
【判断题】
5)Bioavailability of a drug indicates whether a therapeutically effective concentration is achieved at the site(s)of action of that drug.
A. 对
B. 错
【判断题】
(6)Prodrugs are not therapeutically effective unless they are changed into therapeutically active forms before or after reaching the systemic circulation
A. 对
B. 错
【单选题】
（3）生物圈的范围为___
A. 大气圈、水圈和岩石圈的全部
B. 大气圈和水圈的全部、岩石圈的上部
C. 大气圈的底部、水圈和岩石圈的全部
D. 大气圈的底部、水圈的全部和岩石圈的上部
【单选题】
（8）地球的表面积约为5.1亿平方千米，表面起伏不平，凸出来的地方成为陆地和山脉，而大片大片下凹的部分经过亿万年的积累，被液态海水所淹没而变成了海洋，海洋面积占地球表面积的近___。
A. 2％
B. 51%
C. 71%
D. 91%
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C. 75m
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道口轨道电路与ZPW-2000、UM系列轨道电路叠加时，闭路式道口控制器安装地点应距调谐区不小于_______。[311010103]___
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C. 75m
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D. 轨道继电器吸起电阻为1.7Ω～2.7Ω
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DK.SW型道口控制器轨道电路端电压，闭路式和开路式均为_______。[3210101001]___
A. 22V～25V
B. 23V～27V
C. 23.5V～27.5V
D. 30V～38V
【单选题】
DK.SW型道口控制器(无绝缘轨道电路收发器)的电源电压为直流_______。[322010102]___
A. 24V±1.2V
B. 24V
C. 24V±2V
D. 24V±0.5V
【单选题】
97型25Hz相敏轨道电路在调整状态时，轨道继电器轨道线圈上的有效电压应不小于_______。[323010102]___
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B. 16V
C. 18V
D. 20V
【单选题】
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B. 7.4V
C. 8.5V
D. 10.5V
【单选题】
97型25Hz相敏轨道电路轨道继电器至轨道变压器间的电缆电阻不大于_______。[322010103]___
A. 100Ω
B. 120Ω
C. 140Ω
D. 150Ω
【单选题】
CTCS-2列控系统车站入口处的有源应答器的信息丢失时，由于没有临时限速信息，此后机车无法以大于NBP为_______的速度运行。[322000000]___
A. 20km/h
B. 30km/h
C. 40km/h
D. 50km/h
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25Hz相敏轨道电路受电端的电阻器(包括室内、外的)，允许按需要从零至_______对轨道电路进行调整。[322010103]___
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B. 全值
C. 无穷大
D. 70％
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A. 15V～18V
B. 15V～28V
C. 20V～30V
D. 25V～36V
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JXW25型电子接收器的应变时间为_______。[321010103]___
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B. 0.3s～0.5s
C. 0.7s～0.9s
D. 0.7s～0.95s
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交流电力牵引区段，在信号电缆的同一芯线上，任何两点间的感应电动势：在接触网供电状态下，不大于_______。[321010101]___
A. 60V
B. 80V
C. 90V
D. 100V
【单选题】
交流电力牵引区段，在信号电缆的同一芯线上，任何两点间的感应电动势：在接触网故障状态下，感应纵电动势不得超过电缆直流耐压试验电压值的_______。[321010102]___
A. 60%
B. 65%
C. 80%
D. 85%
【单选题】
交流电力牵引区段，在信号电缆的同一芯线上，任何两点间的感应电动势：在接触网故障状态下，感应纵电动势不得超过电缆交流耐压试验电压值的_______。[321010101]___
A. 60%
B. 65%
C. 80%
D. 85%
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【单选题】
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B. 20A
C. 30A
D. 40A
