【单选题】
(8)Once they identify a promising substance, they___ make many one-at-a-time modifications to the structure.___
A. laboriously
B. hardly
C. easy
D. effectively
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相关试题
【单选题】
(9)Often these procedures yield a compound having acceptable___ and safety.___
A. strength
B. effect
C. potency
D. effort
【单选题】
10)In many laboratories today, robots___ the routine work of parallel synthesis.___
A. help
B. assist with
C. assist in
D. assist to
【单选题】
(1)Pharmaceutics is an interdisciplinary subject involving___
A. formulation, manufacturing, physical pharmacy, and biopharmaceutics
B. manufacturing
C. physical pharmacy
D. biopharmaceutics
【单选题】
（2）Formulation is about the design, development and evaluation of dosage forms,___
A. discovery of novel drugs
B. analytical methods
C. drug delivery systems and manufacturing process
D. dosing regimen
【单选题】
(3)Biopharmaceutics mainly studies the in vivo process of drugs and metabolites in humans, animals and tissue culture, which specifically involves___
A. absorption and distribution
B. absorption, distribution, metabolism, and excretion
C. metabolism and excretion
D. absorption and excretion
【单选题】
(4)Regarding the definition of bioavailability(BA), BA is related to___
A. total plasma drug concentration only
B. unbound drug concentration in the plasma
C. unbound drug concentration at the target site
D. total plasma drug concentration, and the administered drug dose
【单选题】
(5)Plasma drug concentration is affected by following factors such as___
A. rate of absorption
B. rate and extent of distribution
C. rate ofeli Imination
D. all ofabove
【单选题】
6)Which of the following routes of administration will involve the absorption of drugs?___
A. i.v.injection
B. i.v.infusion
C. Subcutaneous injection, transdermal and oral
D. None of above
【单选题】
（7）Which of the following factors may influence the time course of a drug in the plasma and hence at its site of action?___
A. Food
B. Disease state
C. Route of administration
D. All of above
【单选题】
(8)Please identify the potential biological barriers for an orally administered tablet to be absorbed into the systemic circulation___
A. Sk d dermis
B. Gastrointestinal epithelium
C. Oral mucosal membrane
D. All of above
【单选题】
(9) Given the same administration dose, which of the following will likely result in varying bioavailabilities for the same drug administered to the same person? ___
A. tablets (p.o. )vs. solutions(p0.)
B. solutions for injection(i v )vs oral solutions(p0.)
C. coated tablets (p.0. )vs hard gelatin capsules(p0.)
D. All ofabove
【单选题】
(10)Which of the following statements is true?___
A. Bioavailability is only related to the administered dose and the total drug concentration in the blood circulation.
B. Plasma protein binding does not affect the bioavailability of a specific drug.
C. A given drug in different dosage forms may show differences in bioavailability if given by the same route.
D. Biopharmaceutical studies do not involve animal experiment.
【判断题】
Much of our present physiological knowledge has been found from the experiments and studies on human beings.
A. 对
B. 错
【判断题】
Living cells break down glucose and fats to provide energy for other activities, which is called.
A. 对
B. 错
【判断题】
The right atriapumps deoxygenated blood to the lungs where it absorbs oxygen from the air.
A. 对
B. 错
【判断题】
The nervous system uses electrical signals to transmit information very rapidly to specific cells.
A. 对
B. 错
【判断题】
With the level of sodium increasing extracelular fruid. the cardiac muscle cells become too excitable and may contract.
A. 对
B. 错
【判断题】
A negative feedback loop is a control system that acts to maintain the level of some variables within a given range following a disturbance
A. 对
B. 错
【判断题】
(1)Pharmacodynamics, which is concerned with the study of the biochemical and physiological effects of drugs and their mechanisms of action, Is an experimental medical science.
A. 对
B. 错
【判断题】
2)It's unreasonable for a physician to be interested mainly in the effects of drugs on human beings, for the pharmacological evaluation of drugs in them may be limited due to technical, legal, and ethical reasons.
A. 对
B. 错
【判断题】
（3） As the effects of drugs are often characterized by significant interspecies variation and may be further modified by disease, clinical pharmacology has never been efibrasized.
A. 对
B. 错
【判断题】
The physician is not interested in drugs that are useful in the prevention,diagnosis,and treatment of human disease, but in chemical agents that are commonly responsible for household and industrial poisoning as well as environmental pollution.
A. 对
B. 错
【判断题】
(5)A drug is said to be useful in therapy if it has the ability to produce its desired effects with only tolerable undesired effects.
A. 对
B. 错
【判断题】
(6)Toxicology deals not only with drugs used in therapy but also with many other chemicals that may be responsible for household, environmental, or industrial intoxication.
A. 对
B. 错
【判断题】
1)With the more efficient screening tests and burgeoning knowledge about how a molecules biological activities are likely to be changed, the traditional approach of discovering new drugs has been improved.
A. 对
B. 错
【判断题】
2)With the parallel synthesis used to identify which small segment of any given large protein would bind to an antibody, Mario Geysen generated a variety of short protein fragments by combining multiple amino acids in different permutations.
A. 对
B. 错
【判断题】
)A parallel synthesis and a split-and-mix synthesis are different in that in a split-and-mix synthesis, all the products are assembled separately n their respective reaction vessels.
A. 对
B. 错
【判断题】
4) In many laboratories, robots are used in the routine work of parallel synthesis to deliver small amounts of reactive molecules into appropriate wells, thus making the process more accurate and less tedious.
A. 对
B. 错
【判断题】
5) In a parallel synthesis, each compound remains in its own container; while in a split-and-min synthesis, the related ce mpounds are mixed up in the same reaction vessel.
A. 对
B. 错
【判断题】
6)In order to solve the difficulties of identifying the compounds made in a parallel synthesis scientists pull out from the mixture the beads that bear biologically active molecules and determine the molecular makeup o d attached.
A. 对
B. 错
【判断题】
1)The concentration of a drug in whole plasma is the most accurate index of the drug concentration at the site（s） of action.
A. 对
B. 错
【判断题】
(2)It is difficult to measure the total concentration of both unbound and bound drug in total plasma.
A. 对
B. 错
【判断题】
(3)The clinical effect of a drug is assumed to be directly related to the plasma drug concentration.
A. 对
B. 错
【判断题】
(4) Systemically acting drugs administered by all routes involve the absorption of drug from the place of administration into the blood.
A. 对
B. 错
【判断题】
5)Bioavailability of a drug indicates whether a therapeutically effective concentration is achieved at the site(s)of action of that drug.
A. 对
B. 错
【判断题】
(6)Prodrugs are not therapeutically effective unless they are changed into therapeutically active forms before or after reaching the systemic circulation
A. 对
B. 错
【单选题】
（3）生物圈的范围为___
A. 大气圈、水圈和岩石圈的全部
B. 大气圈和水圈的全部、岩石圈的上部
C. 大气圈的底部、水圈和岩石圈的全部
D. 大气圈的底部、水圈的全部和岩石圈的上部
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【多选题】
对______的船舶，应当实施卫生除害处理。
A. 来自检疫传染病疫区
B. 被检疫传染病或者监测传染病污染
C. 发现有与人类健康有关的医学媒介生物，超过国家卫生标准
D. 装载活动物入境和拟装运活动物出境
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办理出境检验检疫手续时，船方或者其代理人应当向海关提交______等有关资料（入境时已提交且无变动的可免于提供）。
A. 《航海健康申报书》
B. 《总申报单》
C. 《货物申报单》
D. 《船员名单》
【多选题】
接受入境检疫的船舶，必须按照规定悬挂检疫信号，在检疫完毕以前，不得解除检疫信号。除_______外，其他人员不准上船，不准装卸货物、行李、邮包等物品。
A. 交通工具运营者
B. 引航员
C. 经海关许可的人员
D. 交通工具代理人
【多选题】
特殊物品审批时，直属海关对申请材料应当及时进行书面审查。并可以根据情况采取_____等方式对申请材料的实质内容进行核实。
A. 专家资料审查
B. 现场评估
C. 实验室检测
D. 现场考核
【多选题】
出入境特殊物品有____的，由口岸海关签发《检验检疫处理通知书》，予以退运或者销毁。
A. 名称、批号、规格、生物活性成分等与特殊物品审批内容不相符
B. 超出卫生检疫审批的数量范围
C. 包装不符合特殊物品安全管理要求
D. 经检疫查验不符合卫生检疫要求
【多选题】
______，海关可以根据情节轻重，给予警告或者罚款。
A. 逃避检疫，向国境海关隐瞒真实情况的
B. 入境的人员未经国境海关许可，擅自上下交通工具
C. 装卸行李、货物、邮包等物品，不听劝阻的
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【多选题】
受入境检疫的船舶，在航行中，发现检疫传染病、疑似检疫传染病，或者有人非因意外伤害而死亡并死因不明的，船长必须立即向实施检疫港口的海关报告____。
A. 船名、国籍、预定到达检疫锚地的日期和时间
B. 发航港、最后寄港、船员和旅客人数
C. 货物种类
D. 病名或者主要症状、患病人数、死亡人数以及船上有无船医
【多选题】
发现载有感染检疫传染病病人的入境交通工具，____。
A. 将所有船员集中在一个房间内观察
B. 对染疫人接触过的周围环境、受污染的物品等部位进行必要的杀虫、消毒处理
C. 对病人立即隔离并送医院治疗
D. 卫生检疫人员做好必要的个人防护
【多选题】
在国境口岸发现____，国境口岸有关单位和交通工具的负责人，应当立即向国境海关报告，并申请临时检疫。
A. 检疫传染病
B. 监测传染病
C. 疑似检疫传染病
D. 有人非因意外伤害而死亡并死因不明的
【多选题】
根据《国际卫生条例》，主管当局应该负责监测离开或来自受染地区的行李、货物、集装箱、交通工具、物品和邮包或尸体（骸骨），以便其始终保持无____的状态。
A. 感染源
B. 污染源
C. 媒介
D. 宿主
【多选题】
机场运营方应当在受入境检疫的航空器到达以前，尽早向国境海关通知____。
A. 航空器的国籍、机型、号码、识别标志、预定到达时间
B. 出发站、经停站
C. 机组和旅客人数
D. 航空器负责人姓名
【多选题】
下列关于检疫信号含义的表述，正确是：____。
A. “QQ”字旗表示：本船有染疫或者染疫嫌疑，请立即实施检疫
B. 垂直悬挂红、红、白、红灯四盏表示：本船有染疫或者染疫嫌疑，请立即实施检疫
C. “Q”字旗表示：本船没有染疫，请发给入境检疫证
D. 垂直悬挂红灯三盏表示：本船没有染疫，请发给入境检疫证
【多选题】
______，可被判定为染疫嫌疑船舶。
A. 船舶到达时没有鼠疫病例，但曾经有人在上船六日内患鼠疫的
B. 船上有啮齿动物反常死亡，并死因不明的
C. 船舶在航行中曾经有霍乱病例发生，但在到达前5日内没有发生新病例的
D. 船舶在到达时，离开黄热病疫区没有满6日，或没有满30日并在船上发现黄热病媒介的
【多选题】
_______，可以判定为染疫船舶。
A. 船舶到达时载有染疫人的
B. 船上啮齿动物有反常死亡，并且死因不明
C. 船舶在到达前5日以内，船上曾经有霍乱病例发生
D. 船舶在航行中曾经有黄热病病例发生
【多选题】
入境、出境的____，均应当按照国境卫生检疫法实施细则的规定接受检疫，经海关许可，方准入境或者出境。
A. 人员
B. 交通工具和运输设备
C. 可能传播检疫传染病的货物
D. 可能传播检疫传染病的行李、邮包
【多选题】
对_______人员，国境海关应当区别情况，发给就诊方便卡，实施留验或者采取其他预防、控制措施，并及时通知当地卫生行政部门。
A. 患有监测传染病的
B. 与监测传染病人密切接触的
C. 来自国内监测传染病流行区的
D. 来自国外监测传染病流行区的
【多选题】
“传染病监测”指对特定环境、人群进行_______以及其他有关影响因素的调查研究，预测有关传染病的发生、发展和流行。
A. 临床症状
B. 流行病学
C. 血清学
D. 病原学
【多选题】
来自国内疫区的交通工具，或者在国内航行中发现______，交通工具负责人应当向到达的国境口岸海关报告，接受临时检疫。
A. 检疫传染病
B. 疑似检疫传染病
C. 有人因意外伤害死亡的
D. 有人非因意外伤害而死亡并死因不明的
【多选题】
在国内或者国外检疫传染病大流行的时候，应当立即报请国务院决定采取的检疫措施包括____。
A. 下令封锁陆地边境、国界江河的有关区域
B. 指定某些物品必须经过消毒、除虫，方准由国外运进或者由国内运出
C. 禁止某些物品由国外运进或者由国内运出
D. 指定第一入境港口、降落机场
