【判断题】
67县级以上人民政府应当将旅游应急管理纳入政府应急管理体系,制定应急预 案,建立旅游突发事件应对机制
A. 对
B. 错
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68游艺娱乐场所设置的电子游戏机一律不得向未成年人提供
A. 对
B. 错
【判断题】
69受害的旅游者有权就其应获旅行社赔偿的部分直接向保险公司请求赔偿保险 金
A. 对
B. 错
【判断题】
在国内航空运输中,对每名旅客随身携带的物品,承运人的赔偿责任限额为 每人 3000 元
A. 对
B. 错
【判断题】
从事食品生产、食品销售、餐饮服务以及食用农产品销售,应当依法取得许 可
A. 对
B. 错
【判断题】
消费者因商品缺陷造成人、财产损害的,可以向销售者要求赔偿,也可以向 生产者要求赔偿
A. 对
B. 错
【多选题】
( )是CML治疗方案优化关键依据。
A. 全血细胞计数
B. FISH监测结果
C. PCR监测结果
D. 以上所有选项
【多选题】
( )是入组无治疗缓解试验的首要条件。
A. 达到血液学反应
B. 达到完全细胞遗传学反应
C. 达到主要细胞遗传学反应
D. 持续的DMR
【多选题】
2013年ELN指南推荐,CML-AP/BC患者一线接受( ) 治疗。
A. TKI
B. 干扰素
C. 羟基脲
D. 化疗
【多选题】
2013年ELN指南推荐,伊马替尼不耐受CML-CP患者可接受( ) 治疗。
A. 达沙替尼
B. 尼洛替尼
C. 伊马替尼加量
D. 选项1和2
【多选题】
2013年ELN指南推荐,伊马替尼治疗疗效欠佳的CML-CP患者可接受( )治疗。
A. 维持相同剂量伊马替尼治疗
B. 伊马替尼加量
C. 达沙替尼或尼洛替尼
D. 以上所有选项
【多选题】
2013年ELN指南推荐,伊马替尼治疗失败的CML-CP患者可接受( )治疗
A. 达沙替尼
B. 尼洛替尼
C. alloHSCT
D. 以上所有选项
【多选题】
2016中国CML指南中推荐分子学反应的监测频率为?
A. 每周进行一次,直至确认达到稳定MMR,随后每3个月进行一次
B. 每3个月进行一次,直到获得稳定MMR,随后应每3-6个月检测一次
C. 每3-6个月进行一次,直到获得稳定MMR,随后应每3-6个月检测一次
D. 以上所有选项
【多选题】
2017 ESMO定义的TKI治疗12个月提示治疗警告的指标为
A. "Ph+ 1%-65% ,BCR-ABL 1%-10% "
B. BCR-ABL 0.1%-1%
C. BCR-ABL < 0.1%
D. "Ph+ ≥ 1% , BCR-ABL > 1%"
【多选题】
2017 ESMO定义的TKI治疗3个月达最佳反应标准为
A. "≥ PCyR (Ph+ ≤ 35%) ,BCR-ABL < 10% "
B. "Ph+ 36%-95% ,BCR-ABL > 10% "
C. "CCyR (Ph+ 0) , BCR-ABL < 1% "
D. "Ph+ 1%-65% ,BCR-ABL 1%-10% "
【多选题】
2017 ESMO推荐CML治疗3个月BCR-ABLIS > 10% 达治疗警告时,应对患者
A. 筛查更密切,患者有可能的话换用其他药物治疗
B. 筛查更密切,每月一次
C. 换用其他TKI治疗,继续原TKI治疗或增加伊马替尼剂量为下一步 HCT进行评估
D. 以上都不对
【多选题】
AP和BC分别是指( )。
A. 慢性期和加速期
B. 加速期和急变期
C. 慢性期和急变期
D. 加速期和慢性期
【多选题】
CML患者疾病进展后,中位生存时间不足
A. 2年
B. 6个月
C. 1年
D. 1年3个月
【多选题】
CML预后分析Sokal积分公式中包含( )等预后因素。
A. 年龄、脾脏大小、血小板、原始细胞
B. 年龄、脾脏大小、血小板、嗜酸性细胞百分数
C. 年龄、脾脏大小、血小板、嗜碱性细胞百分数
D. 以上所有选项均错误
【多选题】
CML诊断标准包括( )。
A. 典型的临床表现
B. 有Ph染色体
C. 有BCR-ABL融合基因阳性
D. 典型的临床表现,有Ph染色体和/或有BCR-ABL融合基因阳性
【多选题】
CML治疗的首要目标是使患者维持在( )。
A. 加速期
B. 慢性期
C. 急变期
D. 以上均不正确
【多选题】
CML治疗反应的监测方法包括( )?
A. "全血细胞计数
B. 骨髓细胞遗传学分析
C. 实时定量聚合酶链反应检测(RQ-PCR)
D. 以上均正确
【多选题】
DASISION 研究4年随访中,22%的达沙替尼治疗患者中经常报告的不良事件是()。
A. 浅表水肿
B. 胸腔积液
C. 恶心
D. 疲劳
【多选题】
DASISION研究的终点是( )。
A. 6个月内,证实获得的CCyR
B. 12个月内,证实获得的CCyR
C. 6个月内,证实获得的MMR
D. 12个月内,证实获得的MMR
【多选题】
DASISON 研究中,达沙替尼胸腔积液的复发率是( )。
A. 0.63
B. 0.23
C. 0.91
D. 0.44
【多选题】
ELN推荐,获得MMR的患者,应每( )进行常规IS RQ-PCR监测。
A. 3-6个月
B. 6-12个月
C. 8-10个月
D. 1-2个月
【多选题】
ELN推荐,治疗12个月时的最佳疗效反应为( )。
A. BCR-ABL≤10%和/或CCyR( 0%到35%,Ph+ 染色体)
B. BCR-ABLIS<1%和/或CCyR(0%,Ph+ 中期分裂)
C. BCR-ABL≤0.1%(MMR或更深)
D. BCR-ABL>10%
【多选题】
ELN推荐,治疗3个月时的最佳疗效反应为( )。
A. BCR-ABLIS≤10%和/或PCyR(0%到35%,Ph+中期分裂)
B. BCR-ABLIS<1%和/或CCyR(0%,Ph+ 中期分裂)
C. BCR-ABL≤0.1%(MMR或更深)
D. BCR-ABL>10%
【多选题】
ELN推荐,治疗6个月时的最佳疗效反应为( )。
A. BCR-ABL≤10%和/或PCyR(0%到35%,Ph+ 中期分裂)
B. BCR-ABLIS<1%和/或CCyR(0%,Ph+ 中期分裂)
C. BCR-ABL≤0.1%(MMR或更深)
D. BCR-ABL>10%
【多选题】
ELN推荐患者应该进行常规IS RQ-PCR监测,每( )个月一次,直至获得MMR。
A. 1
B. 2
C. 3
D. 4
【多选题】
EMA 2006年颁布指南:每天摄入遗传毒性杂质应( )。
A. ≤1.5微克
B. =1.5微克
C. >1.5微克
D. 以上所有选项均错误
【多选题】
EMA是指( ) 。
A. 欧洲药品管理局
B. 欧洲白血病网
C. 美国国家综合癌症网络
D. 美国血液病学会
【多选题】
ENESTchina的主要研究终点是( )。
A. 12个月的MMR,定义为BCR-ABL≤0.1%
B. 6个月的MMR,定义为BCR-ABL≤0.1%
C. 24个月的MMR,定义为BCR-ABL≤0.1%
D. 36个月的MMR,定义为BCR-ABL≤0.1%
【多选题】
ENESTchina中,中国CML 发病的中位年龄是( )。
A. 55
B. 60
C. 40
D. 71
【多选题】
ENESTcmr研究中,与使用伊马替尼相比, 使用达希纳实现首次MR4.5的中位时间缩短了
A. 3个月
B. 6个月
C. 1年
D. 2年
【多选题】
ENESTFreedom研究中,巩固期PCR检测频率为
A. 每4周一次
B. 每6周一次
C. 每8周一次
D. 每12周一次
【多选题】
ENESTFreedom研究中,停药后48周维持TFR的患者比例为
A. 0.442
B. 0.516
C. 0.589
D. 0.56
【多选题】
ENESTFreedom研究中,重启达希纳治疗后获得的治疗反应是指
A. 实现CCyR
B. 实现MMR
C. 实现CMR
D. 以上都正确
【多选题】
ENESTFreedom研究中,重启治疗的标准是
A. 丧失MR4.5
B. 丧失MMR
C. 丧失CCyR
D. 疾病进展
【多选题】
ENESTnd 和DASISION研究中伊马替尼二线治疗患者12个月时达MMR的比例不超过
A. 0.3
B. 0.4
C. 0.5
D. 0.6
【多选题】
ENESTnd 研究随访到5年时,达希纳300mgBID和伊马替尼组的患者中,达到MR4.5的患者的百分比是多少?
A. 32%、15%
B. 40%、 23%
C. 42%、 24%
D. 54%、 31%
推荐试题
【单选题】
F. Scott Fitzgerald’s finest novel is , and its theme is about
A. A. The Great Gatsby, the American Dream
B. B. Tender is the Night, love
C. C. Tales of the Jazz Age, the loss of oneself
D. D. The Beautiful and the Damned, the evil of human nature
【单选题】
Of the following writers, is NOT included in the group of naturalists.
A. A. Stephen Crane
B. B. Frank Norris
C. C. Theodore Dreiser
D. D. Herman Melville
【单选题】
Of the following, is NOT characteristic of Mark Twain’s works.
A. A. colloquial speech
B. B. a sense of humor
C. C. a realistic view
D. D. an idealistic view
【单选题】
Of the following, is considered Herman Melville’s masterpiece.
A. A. The Last of the Mohicans
B. B. The Legend of Sleepy Hollow
C. C. Moby Dick
D. D. Daisy Miller
【单选题】
Of the following, is NOT Nathaniel Hawthorne’s work.
A. A. The Scarlet Letter
B. B. The House of the Seven Gables
C. C. The Marble Faun
D. D. Nature
【单选题】
is regarded as “the father of American literature”.
A. A. James Fennimore Cooper
B. B. Ralph Waldo
C. C. Thomas Jefferson
D. D. Washington Irving
【单选题】
Of the following writers, are from the Colonial and Revolutionary Periods.
A. A. Benjamin Franklin & Edgar Ellen Poe
B. B. Edgar Ellen Poe & Jonathan Edwards
C. C. Benjamin Franklin & Jonathan Edwards
D. D. Edgar Ellen Poe & Washington Irving
【单选题】
The National Day of the United States falls on .
A. A. June 4th
B. B. July 4th
C. C. June 14th
D. D. July 14th
【单选题】
Of the following, is NOT among the three major radio and TV networks in America.
A. A. the National Broadcasting System (NBS)
B. B. the Public Broadcasting Service (PBS)
C. C. the Columbia Broadcasting System (CBS)
D. D. the American Broadcasting System (ABS)
【单选题】
is sold especially to the upper or upper-middle class and it has a reputation for its serious attitude and great bulk.
A. A. The Washington Post
B. B. The New York Times
C. C. Los Angeles Times
D. D. New York Daily News
【单选题】
Of the following universities, has NOT cultivated any American President yet.
A. A. Harvard University
B. B. Massachusetts Institute of Technology
C. C. Princeton University
D. D. Yale University
【单选题】
To get a bachelor’s degree, all undergraduate students are required to do the following except .
A. A. attending lectures and completing assignments
B. B. passing examinations
C. C. working for communities
D. D. earning a certain number of credits
【单选题】
Of the following, is NOT the responsibility of the board of trustees in U. S. institutions.
A. A. choosing the president
B. B. establishing policies for administrators and faculty
C. C. approving budget and other financial project
D. D. decide which student to enroll
【单选题】
Of the following, are NOT among the categories of American higher education.
A. A. universities and colleges
B. B. research institutions
C. C. technical institutions
D. D. community colleges
【单选题】
Higher education in the United States began with the founding of
A. A. Yale University
B. B. Harvard University
C. C. Princeton University
D. D. New York University
【单选题】
Of the following subjects, are NOT offered to elementary school students.
A. A. mathematics and languages
B. B. politics and business education
C. C. science and social studies
D. D. music and physical education
【单选题】
Formal education in the United States consists of , secondary and higher education.
A. A. kindergarten
B. B. public
C. C. elementary
D. D. private
【单选题】
At present, U. S. exports account for of the world’s total.
A. A. 10%
B. B. 15%
C. C. 20%
D. D. 25%
【单选题】
is not one of the three giants in American automobile industry.
A. A. Ford
B. B. General Motors
C. C. Chrysler
D. D. American Motors
【单选题】
The following statements are all true except .
A. A. Agribusinesses reflect the big, corporate nature of many farm enterprises.
B. B. Agribusinesses maintain a balanced trade pattern between agricultural imports and exports.
C. C. Agribusinesses range from one-family corporations to multinational firms.
D. D. Agribusinesses include a variety of farm businesses and structures.
【单选题】
About of American crops are for export.
A. A. half
B. B. one third
C. C. one fourth
D. D. one fifth
【单选题】
President Johnson tried to build a “Great Society” by introducing various programs like the following except .
A. A. Medicare
B. B. Food Stamps
C. C. Education Initiatives
D. D. Unemployment Pension
【单选题】
The following inventions took place during the “second indThe following inventions took place during the “second industrial revolution” except .
A. A. typewriter
B. B. telephone
C. C. electric light
D. D. refrigerator
【单选题】
The first National Bank of the United States was established with the urge of .
A. A. George Washington
B. B. Thomas Jefferson
C. C. Andrew Jackson
D. D. Alexander Hamilton
【单选题】
Chartered companies were NOT granted the by the British King or Queen.
A. A. political authority
B. B. economic rights
C. C. judicial authority
D. D. diplomatic authority
【单选题】
The modern American economy progressed from to , and eventually, to .
A. A. colonial economy, handcraft economy, industrial economy
B. B. farming economy, handcraft economy, industrial economy
C. C. colonial economy, farming economy, industrial economy
D. D. handcraft economy, farming economy, industrial economy
【单选题】
America produces a major portion of the world’s products in the following fields except .
A. A. machinery
B. B. automobiles
C. C. ore
D. D. chemicals
【单选题】
The President is directly voted into office by .
A. A. all citizens of America
B. B. the citizens over 18 years old
C. C. electors elected by the voters
D. D. the senators and representatives
【单选题】
The Supreme Court is composed of justices.
A. A. six
B. B. seven
C. C. eight
D. D. nine
【单选题】
The terms for a Senator and Representative are and years respectively.
A. A. two, four
B. B. two, three
C. C. two, six
D. D. six, two
【单选题】
According to the Constitution, a candidate for President must be .
A. A. at least 35 years old
B. B. at least a 14 years’ resident of the United States
C. C. born in America
D. D. all of the above
【单选题】
The following except are all powers of the President.
A. A. vetoing any bills passed by Congress
B. B. appointing federal judges when vacancies occur
C. C. making laws
D. D. issuing executive orders
【单选题】
All the following except cannot make legislative proposal.
A. A. the Senator
B. B. the Representative
C. C. the Secretary of State
D. D. the President
【单选题】
The following except are guaranteed in the Bill of Rights.
A. A. freedom of religion
B. B. the right to get into people’s house by police
C. C. freedom of speech and of press
D. D. the right to own one’s weapon if one wishes
【单选题】
The Bill of Rights .
A. A. defines the rights of Congress and the rights of the President
B. B. guarantees citizens of the United States specific individual rights and freedoms
C. C. is part of the Declaration of Independence
D. D. has no relationship with the Constitution
【单选题】
The Constitution of the United States .
A. A. gives the most power to Congress
B. B. gives the most power to the President
C. C. tries to give each branch enough power to balance the others
D. D. gives the most power to the Supreme Court
【单选题】
The U. S. Constitution came into effect in .
A. A. 1787
B. B. 1789
C. C. 1791
D. D. 1793
【单选题】
The Vietnam War was a long-time suffering for Americans, and it continued throughout the terms of Presidents .
A. A. Johnson, Nixon and Ford
B. B. Truman, Eisenhower and Kennedy
C. C. Kennedy, Johnson and Nixon
D. D. Eisenhower, Kennedy and Johnson
【单选题】
President applied New Deal to deal with the problems of the Great Depression.
A. A. Wilson
B. B. Truman
C. C. Roosevelt
D. D. Kennedy
【单选题】
The policy of the United States was at the beginning of the two world wars.
A. A. neutrality
B. B. full involvement
C. C. partial involvement
D. D. appeasement